Nephrogenic diabetes insipidus occurs when the kidney is unable to produce concentrated urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate. Renal impairment: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure. "Chlorthalidone." [20], Chlortalidone may improve edema (swelling) by increasing urinary salt and water excretion, lowering intravascular hydrostatic pressure and thereby lowering transcapillary pressure (see Starling Equation). Description and Brand Names. [25], Chlortalidone reduces the amount of calcium excreted in urine, reducing the risk of calcium oxalate kidney stones. Diuretics such as chlortalidone also reduce the urine concentration of concomitantly-taken performance-enhancing drugs or of their metabolites, thus making it more difficult to detect these drugs using urine testing. [1] Effects generally begin within three hours and last for up to three days. 100,101 This difference in duration of action by chlorthalidone translated into an additional 7-mm Hg reduction in SBP when substituted for hydrochlorothiazide. [28], Chlortalidone reduces the volume and thereby reduces the pressure in the inner ear chambers; elevated endolymph pressure in the inner ear is thought to be the cause of Ménière's disease or ’Endolymphatic hydrops.’ Synthesis of evidence from multiple small, low-quality studies indicates that chlortalidone or other thiazide diuretics are effective for Ménière's Disease. Definition of chlorthalidone in the Definitions.net dictionary. Chlortalidone is the official name of the medication according to the (INN/BAN), which is the medication naming system coordinated by the World Health Organization. Brand Name : Contains: Dosage Form : Manufacturer: Price(Tk.) Academic Press, 1985. As it lacks the benzothiadiazine structure of the thiazide-type diuretics, it is called a thiazide-like diuretic. Chlorthalidone systemic is used in the treatment of: Edema. Edema may be caused by either increased hydrostatic pressure or reduced oncotic pressure in the blood vessels. It increases the amount of urine you make, especially when you first start the medication. Chlorthalidone brands in India - Atecard-D from Dabur , Catapres-DIU from Zydus (G. Rem) , Clothalton from SPPL , Ctd from IPCA , Eritel-CH from Eris , Hythalton from SPPL , Tenoclor from AHPL , Tenoric from IPCA , Thalizide from IPCA , Vinicor-D from IPCA , , drugsupdate.com - India's leading online platform for Doctors and health care professionals. [1][2] In high blood pressure it is a preferred initial treatment. Side effects, drug interactions, dosing information, and pregnancy safety should be reviewed prior to … Eventually, cardiac output returns to normal, and plasma and extracellular fluid volume return to slightly less than normal, but a reduction in peripheral vascular resistance is maintained, thus resulting in an overall lower blood pressure. Edema due to decreased oncotic pressure may be a result of leaking of blood proteins through the glomeruli of an injured kidney[21] or a result of decreased synthesis of blood proteins by the liver. Regardless of cause, chlortalidone may sometimes improve the severity of edema by reducing intravascular volume and thereby reducing intravascular hydrostatic pressure. This reduced delivery of solute to the collecting tubule and medullary collecting duct allows increased water resorption and higher concentration of urine, which leads to reversal of nephrogenic diabetes insipidus by a means that is independent of vasopressin. [1], Chlortalidone was patented in 1957 and came into medical use in 1960. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. 100 apical ROMK/Na channels coupled with basolateral Na+/K ATPases). chlorothiazide systemic. By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. Chlorthalidone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. Drug Name : Chlorthalidone. ... a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks. It is also used to prevent calcium-based kidney stones. Summary. It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. Chlorthalidone oral tablet is only available as a generic drug.It doesn’t have a brand-name version. [1] It is also used to prevent calcium-based kidney stones. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for high blood pressure and fluid retention. [29], Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. Grim on brand name for chlorthalidone: Normal BP in a 29yo is 750 mg. Chlortalidone's diuretic effect is diminished in persons with kidney impairment. [46] Chlortalidone may suppress lactation, and has been used for this indication. [17][18], Chlortalidone is used to treat left ventricular hypertrophy in the heart; it works chiefly by lowering blood pressure, and thereby reducing systemic vascular resistance. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. It is taken by mouth. Chlortalidone reduces reabsorption of sodium and chloride primarily through inhibition of the Na+/Cl− symporter in the apical membrane of distal convoluted tubule cells in the kidney. Contraindications. [1], Common side effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction. It helps the kidney to get rid of unwanted water and salt from the body into the urine. In Analytical Profiles of Drug Substances, vol. * Drug Price mentioned in Indian Rupees (, Updation of information may not have happened at the right time. Chlorthalidone is used alone or together with other medicines to treat high blood pressure (hypertension). Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. Chlortalidone is banned for some sports (including cricket) because it is a diuretic, and can be used to reduce body weight or to mask the concomitant use of performance-enhancing drugs. PubChem Compound Database; CID=2732, enlargement of the left ventricle of the heart, "Chlorthalidone Monograph for Professionals", "Thiazide-associated hyponatremia in the elderly: what the clinician needs to know", "Treatment of Resistant and Refractory Hypertension", "Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis", "Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium-sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta-analysis", "Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic", "Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline", "Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in CKD", "Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone", "Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults: Secondary Analysis of a Randomized Clinical Trial", "Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline", "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis", "A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? Effects generally begin within three hours and last for up to three days. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. ", "Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia", "Thiazide-Associated Hypercalcemia: Incidence and Association With Primary Hyperparathyroidism Over Two Decades", "Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies", "The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs", "Chlorthalidone: don't call it "thiazide-like" anymore", "Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response", "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis", "Yasir Shah provisionally suspended after failed drugs test", https://en.wikipedia.org/w/index.php?title=Chlortalidone&oldid=992686053, World Anti-Doping Agency prohibited substances, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 December 2020, at 15:54. What is chlortalidone? Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Chlorothiazide systemic is used in the treatment of: Edema. [1][2][4] Some reviews have found chlortalidone to have a higher risk of side effects than hydrochlorothiazide,[5][6] while other reviews have found a similar risk. [22], Chlortalidone decreases mineral bone loss by promoting calcium retention by the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. Chlortalidone is used to treat high blood pressure (hypertension), and is also used to lessen extra fluid in the body (called oedema) caused by conditions such as heart failure, liver disease, or kidney disease. Chlorthalidone is the official name of the medication according to the (USAN), which is the medication naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). 1-36. They are available as follows: NDC 16714-128-01 in bottle of 100 tablets This medication is used to treat high blood pressure (hypertension). Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2021. This site complies with the HONcode standard for trustworthy health information: verify here. Disclaimer - All information and content on this site are for information and educational purposes only. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. chlorthalidone systemic. High blood pressure or hypertension is a chronic condition, which usually lasts a lifetime once it is developed. Chlorthalidone manufacturer,Chlorthalidone 15mg,clonidine hcl 0.1mg,Chlorthalidone 100mg,Chlorthalidone 12.5mg Largest Generic Manufacturer,Formula,producing With chemical method according to the present invention Suppliers List,Molecular Structure,Weight,IUPAC,Synonyms for Chlorthalidone Edema due to increased hydrostatic pressure may be a result of serious cardiopulmonary disease (which reduces glomerular perfusion in the kidney) or to kidney injury or disease (which may reduce glomerular excretion of salt and water by the kidney) or due to relatively benign conditions such as menstrual-related fluid retention, or as an adverse effect of dihydropyridine calcium channel blockers, which commonly cause swelling of the feet and lower legs. [43] Chronic exposure to chlortalidone decreases the glomerular filtration rate. Description and Brand Names. Anuria. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. 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By either increased hydrostatic pressure or hypertension is a preferred initial treatment Ltd. 30s pack 60.00. Increases the amount of urine you make, especially when you first start medication. 1957 and came into medical use in pregnancy: it is also sold as a tablet take... Effects generally begin within three hours and last for up to three days nephrogenic diabetes insipidus with... And fluid retention caused by congestive heart failure and other conditions and kidney problems chlorthalidone translated an!, in persons with kidney disease than the placebo or magnesium hydroxide ( p than! Yellowish-White crystalline powder: Dosage form: Manufacturer: Price ( Tk. congestive heart failure other. O'Hare, Carl R. Rehm, and Chlorthalid as it crosses the placenta is! Reduced and the elimination half-life is increased more effective prolonged action of chlortalidone 's effect... 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